ZNF292

ZNF654

ZNF654 is considerably more divergent from ZNF292 than is RLF, especially in it’s array of zinc fingers, but is also has a very similar N-terminal domain. A function for ZNF654 has not yet been proposed.

Location:
chr 3: + 3p11.1 GRCh37.p13 88,188,254-88,193,815 GRCh38.p12 88,059,274-88,144,665
HGNC: 25612 NM013501341 NP0013370631

Alterante names:
Melanoma-Associated Antigen

ZNF654 Domain Analysis

Estimated weight: 127.876KDa

10 20 30 40 50 MAEEESDQEA ERLGEELVAI VESPLGPVGL RAAGDGRGGA GSGNCGGGVG 60 70 80 90 100 ISSRDYCRRF CQVVEDYAGR WQVPLPQLQV LQTALCCFTT ASASFPDECE 110 120 130 140 150 HVQYVLSSLA VSFFELLLFF GRDEFYEEPL KDILGSFQEC QNHLRRYGNV 160 170 180 190 200 NLELVTRIIR DGGPWEDPVL QAVLKAQPAS QEIVNKYLSS ENPLFFELRA 210 220 230 240 250 RYLIACERIP EAMALIKSCI NHPEISKDLY FHQALFTCLF MSPVEDQLFR 260 270 280 290 300 EHLLKTDCKS GIDIICNAEK EGKTMLALQL CESFLIPQLQ NGDMYCIWEL 310 320 330 340 350 IFIWSKLQLK SNPSKQVFVD QCYQLLRTAT NVRVIFPFMK IIKDEVEEEG 360 370 380 390 400 LQICVEICGC ALQLDLHDDP KTKCLIYKTI AHFLPNDLEI LRICALSIFF 410 420 430 440 450 LERSLEAYRT VEELYKRPDE EYNEGTSSVQ NRVRFELLPI LKKGLFFDPE 460 470 480 490 500 FWNFVMIKKN CVALLSDKSA VRFLNESTLE NNAGNLKRTE EQQGLDEGFD 510 520 530 540 550 SLTDQSTGET DPDDVSGVQP KGHINTKKNL TALSTSKVDH NVPRHRCMLC 560 570 580 590 600 NKEFLGGHIV RHAQAHQKKG SFACVICGRK FRNRGLMQKH LKNHVKKIQR 610 620 630 640 650 QQIAAAQQDD QEVTALEEIN CSSSSISFEN GNSDSKDLEV ETLTASSEGN 660 670 680 690 700 KEVIPEHVAE FIEIPISVPE DVIENVIENG SPNNSLNNVF KPLTECGDDY 710 720 730 740 750 EEEEDEEGDY EEDDYDLNQE TSVIHKINGT VCHPKDIYAT DQEGNFKCPA 760 770 780 790 800 LGCVRIFKRI GFLNKHAMTV HPTDLNVRQT VMKWSKGKCK FCQRQFEDSQ 810 820 830 840 850 HFIDHLNRHS YPNVYFCLHF NCNESFKLPF QLAQHTKSHR IFQAQCSFPE 860 870 880 890 900 CHELFEDLPL LYEHEAQHYL SKTPESSAQP SETILWDVQT DSNPNQEKDS 910 920 930 940 950 SSNEKQTISL PVSTSKSRKE STEPKTCIES MEKKTDSLVQ NGNERSDDTV 960 970 980 990 1000 SNISLIDQKM PDIEPNSENN CSSSDIVNGH SEIEQTPLVS SDPALKIDTN 1010 1020 1030 1040 1050 RIRTENGSIL PSVVPQEHNT LPVSQAPSKP NLTSEHTSYG LILTKPYVRP 1060 1070 1080 1090 1100 LPPSYLDERY LSMPKRRKFL TDRVDACSDQ DNVYKKSVKR LRCGKCLTTY 1110 1120 CNAEALEAHL AQKKCQTLFG FDSDDESA

Zinc fingers predicted by zf.princeton.edu

CMLCNKEFLGGHIVRHAQAH 7.8 548 CVICGRKFRNRGLMQKHLKNH 28.0 574 CPALGCVRIFKRIGFLNKHAMTVH 18.9 748 CKFCQRQFEDSQHFIDHLNRH 17.5 789 CLHFNCNESFKLPFQLAQHTKSH 18.3 817 CSFPECHELFEDLPLLYEHEAQH 12.9 846 CGKCLTTYCNAEALEAHLAQKKC 12.9 1093

SMART Predictions (high confidence)
feature start end E-value low complexity 29 54 low complexity 72 82 ZnF_C2H2 545 566 21.7 ZnF_C2H2 572 594 0.00169 low complexity 598 611 low complexity 617 635 low complexity 697 716 ZnF_C2H2 746 771 0.176 ZnF_C2H2 787 809 0.465 ZnF_C2H2 815 839 0.498 ZnF_C2H2 844 868 7.49 ZnF_C2H2 1091 1111 149

cNLS Mapper Results (6+)
1059 RYLSMPKRRKFLTDRVDACSDQDNVYKKSVKR 9.4

NucPred Results (Overall score 0.92)
1062 MPKRRKFLT

ZNF654 to ZNF292 Alignment

ZNF292 vs ZNF654

ZNF292 to ZNF654 Alignment in MVIEW format

ZNF292 MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLR------ESRVPAV **:**::** ** . . ** . : * :. . ZNF654 MAEEESDQEAERLGEELVAIVESPLGPVGLRAAGDGRGGAGSGNCGGGVG ZNF292 EAATDYCQQLCQTLLEYAEKWKTSEDPLPLLEVYTVAIQSYVKARPYLTS :: ***:::**.: :** :*:.. ** *:* .*: .:..* . :.. ZNF654 ISSRDYCRRFCQVVEDYAGRWQVP---LPQLQVLQTALCCFTTASASFPD ZNF292 ECENVALVLERLALSCVELLLCLP-VELSDKQWEQFQTLVQVAHEKLMEN ***:* **. **:* .**** : *: :: ::: .* .:::* . ZNF654 ECEHVQYVLSSLAVSFFELLLFFGRDEFYEEPLKDILGSFQECQNHLRRY ZNF292 GSCELHFLATLAQETGVWKNPVLCTILSQEPLDKDKVNEFLAFEGPILLD *. :*.::: : :: * *::*** ::*. :* .:: **::*: *.*:::: ZNF654 GNVNLELVTRIIRDGGPWEDPVLQAVLKAQPASQEIVNKYLSSENPLFFE ZNF292 MRIKHLIKTNQLSQATALAKLCSDHPEIGIKGSFKQTYLVCLCTS-SPNG :* ::** :::.:* ** * * :****. . *:*: :.** * : ZNF654 LRARYLIACERIPEAMALIKSCINHPEISKDLYFHQALFTCLFMSPVEDQ ZNF292 KLIEEISEVDCKDALEMICNLESEGDEKSALVLCTAFLSRQLQQGDMYCA : *.: :.***..:::*** *.**. ** ** :** ***:***** ZNF654 LFREHLLKTDCKSGIDIICNAEKEGKTMLALQLCESFLIPQLQNGDMYCI ZNF292 WELTLFWSKLQQRVEPSIQVYLERCRQLSLLTKTVYHIFFLIKVINSETE *** ::***** : :** **::::* ** :..* ** ::*:*:.*.* ZNF654 WELIFIWSKLQLKSNPSKQVFVDQCYQLLRTATNVRVIFPFMKIIKDEVE ZNF292 GAGLATCIELCVKALRLESTENTEVKISICKTISCLLPDDLEVKRACQLS ** *:*:* **:*: ::.:.* * ***: :**:***: * * ** ZNF654 EEGLQICVEICGCALQLDLHDDPKTKCLIYKTIAHFLPNDLEILRICALS ZNF292 EFLIEPTVDAYYAVEMLYNQPDQKYDEENLPIPNSLRCELLLVLKTQWPF *::* :::** :** **::**::*:* . .: * :* *** :**. * ZNF654 IFFLERSLEAYRTVEELYKRPDEEYNEGTSSVQNRVRFELLPILKKGLFF ZNF292 DPEFWDWKTLKRQCLALMGEEASIVSSIDELNDSEVYEKVVDYQEESKET *****:: :*::*:**:.::::: :. :.:. : :::. : ZNF654 DPEFWNFVMIKKNCVALLSDKSAVRFLNESTLENNAGNLKRTEEQQGLDE ZNF292 SMNGLSGGVGANSGLLKDIGDEKQKKREIKQLRERGFISARFRNWQAYMQ .::.*:. .::. . * * * .*: :: :*: : :. : ZNF654 GFDSLTDQSTGETDPDDVSG--VQPKGHINTKKNLTALSTSKVDHNVPRH ZNF292 YCVLCDKEFLGHRIVRHAQKHYKDGIYSCPICAKNFNSKETFVPHVTLHV *:**:***** :****** * *.* ::* **.::*..: : *:. ** ZNF654 RCMLCNKEFLGGHIVRHAQAHQKKGSFACVICGRKFRNRGLMQKHLKNHV ZNF292 KQSSKERLAAMKPLRRLGRPPKITTTNENQKTNTVAKQEQRPIKKNSLYS *: .::::** : .** .::: . * ZNF654 KKIQRQQIAAAQQD----------------------DQEVTALEEINCSS ZNF292 TDFIVFNDNDGSDDENDDKDKSYEPEVIPVQKPVPVNEFNCPVTFCKKGF :.: . *.*..*.* ZNF654 SSISFENGNSDSKD------------------------------------ ZNF292 KYFKNLIAHVKGHKDNEDAKRFLEMQSKKVICQYCRRHFVSVTHLNDHLQ ZNF654 -------------------------------------------------- ZNF292 MHCGSKPYICIQMKCKAGFNSYAELLTHRKEHQVFRAKCMFPKCGRIFSE ZNF654 -------------------------------------------------- ZNF292 AYLLYDHEAQHYNTYTCKFTGCGKVYRSQGELEKHLDDHSTPPEKVLPPE : * * ::*:* . ZNF654 ------------------------------LEVETLTASSEGNKEVIPEH ZNF292 AQLNSSGDSIQPSEVNQNTAENIEKERSMLPSENNIENSLLADRSDAWDK . . *.:* :*. ** * ** *.:: ::. *. ZNF654 VAEFIEIPISVPEDVIENVIENG--------SPNNSLNNVFKPLTECGDD ZNF292 SKAESAVTKQDQISASELRQANGPLSNGLENPATTPLLQSSEVAVSIKVS : *. : : . :*.* . ZNF654 YEEEEDEEGDYEEDDYDLNQET---------------------------- ZNF292 LNQGIEDNFGKQENSTVEGSGEALVTDLHTPVEDTCNDLCHPGFQERKEQ : :.. . :*** .:* ZNF654 -----------------------------SVIHKINGTVCHPKDIYATDQ ZNF292 DCFNDAHVTQNSLVNSETLKIGDLTPQNLERQVNNLMTFSVQNQAAFQNN : ZNF654 EGN----------------------------------------------- ZNF292 LPTSKFECGDNVKTSSNLYNLPLKTLESIAFVPPQSDLSNSLGTPSVPPK ZNF654 -------------------------------------------------- ZNF292 APVQKFSCQVEGCTRTYNSSQSIGKHMKTAHPDQYAAFKMQRKSKKGQKA *.* . **.* :: :.** *.** : . : * .**: ZNF654 -----FKCPALGCVRIFKRIGFLNKHAMTVHPTDLNVRQTVMKWSKGK-- ZNF292 NNLNTPNNGKFVYFLPSPVNSSNPFFTSQTKANGNPACSAQLQHVSPPIF ZNF654 -------------------------------------------------- ZNF292 PAHLASVSTPLLSSMESVINPNITSQDKNEQGGMLCSQMENLPSTALPAQ ZNF654 -------------------------------------------------- ZNF292 MEDLTKTVLPLNIDSGSDPFLPLPAESSSMSLFPSPADSGTNSVFSQLEN ZNF654 -------------------------------------------------- ZNF292 NTNHYSSQIEGNTNSSFLKGGNGENAVFPSQVNVANNFSSTNAQQSAPEK ZNF654 -------------------------------------------------- ZNF292 VKKDRGRGPNGKERKPKHNKRAKWPAIIRDGKFICSRCYRAFTNPRSLGG *. * * * :.: : . ZNF654 ----------------------------------CKFCQRQFEDSQHFID ZNF292 HLSKRSYCKPLDGAEIAQELLQSNGQPSLLASMILSTNAVNLQQPQQSTF **.::** : ZNF654 HLNRHSYPN----------------------------------------- ZNF292 NPEACFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQ ZNF654 -------------------------------------------------- ZNF292 ALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPTVPPLLHTVCH ZNF654 -------------------------------------------------- ZNF292 PNTLLTNQNRTSNSKTSSIEECSSLPVFPTNDLLLKTVENGLCSSSFPNS ZNF654 -------------------------------------------------- ZNF292 GGPSQNFTSNSSRVSVISGPQNTRSSHLNKKGNSASKRRKKVAPPLIAPN ZNF654 -------------------------------------------------- ZNF292 ASQNLVTSDLTTMGLIAKSVEIPTTNLHSNVIPTCEPQSLVENLTQKLNN ZNF654 -------------------------------------------------- ZNF292 VNNQLFMTDVKENFKTSLESHTVLAPLTLKTENGDSQMMALNSCTTSINS ZNF654 -------------------------------------------------- ZNF292 DLQISEDNVIQNFEKTLEIIKTAMNSQILEVKSGSQGAGETSQNAQINYN ZNF654 -------------------------------------------------- ZNF292 IQLPSVNTVQNNKLPDSSPFSSFISVMPTKSNIPQSEVSHKEDQIQEILE ZNF654 -------------------------------------------------- ZNF292 GLQKLKLENDLSTPASQCVLINTSVTLTPTPVKSTADITVIQPVSEMINI * ::: ZNF654 -------------------------------------------VYFCLHF ZNF292 QFNDKVNKPFVCQNQGCNYSAMTKDALFKHYGKIHQYTPEMILEIKKNQL : *:..: ** :: .: : :. * . ::.: * : . :: * ZNF654 NCNESFKLPFQLAQHTKSHRIFQAQCSFPECHELFEDLPLLYEHEAQHYL ZNF292 KFAPFKCVVPTCTKTFTRNSNLRAHCQLVHHFTTEEMVKLKIKRPYGRKS . :* ... *: * : ::: ..: : . :: :.* :. . .**. ZNF654 SKTPESSAQPSETILWDVQTDSNPNQEKDSSSNEKQTISLPVSTSKSRKE ZNF292 QSENVPASRSTQVKKQLAMTEENKKESQPALELRAETQNTHSNVAVIPEK .:* .. .* : *.: : : *:: :::* **:::* :* ZNF654 STEPKTCIESMEKKTDSLVQNGNER-----------SDDTVSNISLIDQK ZNF292 QLVEKKSPDKTESSLQVITVTSEQCNTNALTNTQTKGRKIRRHKKEKEEK : ..::. ** :::. ** :* ::. : . .* :.*: . ZNF654 MPDIEPNSENNCSSSDIVNGHSEIEQTPLVSSDPALKIDTNRIRTENGSI ZNF292 KRKKPVSQSLEFPTRYSPYRPYRCVHQGCFAAFTIQQNLILHYQAVHKSD . .: :*. :* :* .: .:. : : ZNF654 LPSVVPQEHNTLPVSQAPSKPNLTSEHTSYGLILTKP------------- ZNF292 LPAFSAEVEEESEAGKESEETETKQTLKEFRCQVSDCSRIFQAITGLIQH ZNF654 -------------------------------------------------- ZNF292 YMKLHEMTPEEIESMTASVDVGKFPCDQLECKSSFTTYLNYVVHLEADHG ZNF654 -------------------------------------------------- ZNF292 IGLRASKTEEDGVYKCDCEGCDRIYATRSNLLRHIFNKHNDKHKAHLIRP :* : .: *:: : : ZNF654 ------------------------------YVRPLPPSYLDERYLSMPKR ZNF292 RRLTPGQENMSSKANQEKSKSKHRGTKHSRCGKEGIKMPKTKRKKKNNLE *:: ..: : .*. :: .** :* ZNF654 RKFLTDRVDACSDQDNVYKKSVKR-------------------------- ZNF292 NKNAKIVQIEENKPYSLKRGKHVYSIKARNDALSECTSRFVTQYPCMIKG ZNF654 -------------------------------------------------- ZNF292 CTSVVTSESNIIRHYKCHKLSKAFTSQHRNLLIVFKRCCNSQVKETSEQE :* * .:: . . : :: *:: . *::* ZNF654 --------------LRCGKCLTTYCNAEALEAHLAQKKCQTLFGFDSDDE ZNF292 GAKNDVKDSDTCVSESNDNSRTTATVSQKEVEKNEKDEMDELTELFITKL .* ZNF654 SA------------------------------------------------ ZNF292 INEDSTSVETQANTSSNVSNDFQEDNLCQSERQKASNLKRVNKEKNVSQN ZNF654 -------------------------------------------------- ZNF292 KKRKVEKAEPASAAELSSVRKEEETAVAIQTIEEHPASFDWSSFKPMGFE ZNF654 -------------------------------------------------- ZNF292 VSFLKFLEESAVKQKKNTDKDHPNTGNKKGSHSNSRKNIDKTAVTSGNHV ZNF654 -------------------------------------------------- ZNF292 CPCKESETFVQFANPSQLQCSDNVKIVLDKNLKDCTELVLKQLQEMKPTV ZNF654 -------------------------------------------------- ZNF292 SLKKLEVHSNDPDMSVMKDISIGKATGRGQY ZNF654 -------------------------------

ZNF654 Raw Sequence
>ZNF654 Zinc finger protein 654 OS=Homo sapiens OX=9606 GN=ZNF654 PE=1 SV=1 MAEEESDQEAERLGEELVAIVESPLGPVGLRAAGDGRGGAGSGNCGGGVGISSRDYCRRF CQVVEDYAGRWQVPLPQLQVLQTALCCFTTASASFPDECEHVQYVLSSLAVSFFELLLFF GRDEFYEEPLKDILGSFQECQNHLRRYGNVNLELVTRIIRDGGPWEDPVLQAVLKAQPAS QEIVNKYLSSENPLFFELRARYLIACERIPEAMALIKSCINHPEISKDLYFHQALFTCLF MSPVEDQLFREHLLKTDCKSGIDIICNAEKEGKTMLALQLCESFLIPQLQNGDMYCIWEL IFIWSKLQLKSNPSKQVFVDQCYQLLRTATNVRVIFPFMKIIKDEVEEEGLQICVEICGC ALQLDLHDDPKTKCLIYKTIAHFLPNDLEILRICALSIFFLERSLEAYRTVEELYKRPDE EYNEGTSSVQNRVRFELLPILKKGLFFDPEFWNFVMIKKNCVALLSDKSAVRFLNESTLE NNAGNLKRTEEQQGLDEGFDSLTDQSTGETDPDDVSGVQPKGHINTKKNLTALSTSKVDH NVPRHRCMLCNKEFLGGHIVRHAQAHQKKGSFACVICGRKFRNRGLMQKHLKNHVKKIQR QQIAAAQQDDQEVTALEEINCSSSSISFENGNSDSKDLEVETLTASSEGNKEVIPEHVAE FIEIPISVPEDVIENVIENGSPNNSLNNVFKPLTECGDDYEEEEDEEGDYEEDDYDLNQE TSVIHKINGTVCHPKDIYATDQEGNFKCPALGCVRIFKRIGFLNKHAMTVHPTDLNVRQT VMKWSKGKCKFCQRQFEDSQHFIDHLNRHSYPNVYFCLHFNCNESFKLPFQLAQHTKSHR IFQAQCSFPECHELFEDLPLLYEHEAQHYLSKTPESSAQPSETILWDVQTDSNPNQEKDS SSNEKQTISLPVSTSKSRKESTEPKTCIESMEKKTDSLVQNGNERSDDTVSNISLIDQKM PDIEPNSENNCSSSDIVNGHSEIEQTPLVSSDPALKIDTNRIRTENGSILPSVVPQEHNT LPVSQAPSKPNLTSEHTSYGLILTKPYVRPLPPSYLDERYLSMPKRRKFLTDRVDACSDQ DNVYKKSVKRLRCGKCLTTYCNAEALEAHLAQKKCQTLFGFDSDDESA