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HOME CONSERVATION C-TERMINAL ANALYSES DNA AND RNA SEQUENCES RESEARCH QUESTIONS RESULTS RESOURCES REFERENCES |
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HOME CONSERVATION C-TERMINAL ANALYSES DNA AND RNA SEQUENCES RESEARCH QUESTIONS RESULTS RESOURCES REFERENCES |
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Location: Chr 6: + 6q14.3 GRCh37.p13 87,865,269-87,973,926 GRCh38.p12 87,155,549-87,265,943 HGCN:1840 NM_015021.1 NP_055836.1 Alterante names: ZFP292 (mouse, rat), ZN-16 (mouse), ZN-15 (rat), Nbla00365, BA3912.3, KIAA0530 ZNF292 is a highly conserved C2H2 zinc finger protein first appearing in vertebrates. The reference sequence databases show it to be composed of 8 exons, the last of which is considerably larger than the others and contains all 16 zinc fingers. Many of the introns are quite large including the first which is over 53Kb in human. This arrangement of large introns with most the protein coded by the last exon is also highly conserved. The canonical transcript predicts a protein of 2723aa (human) which is restricted to the nucleus. A second transcript predicts a slightly shorter protein (2578aa) omitting the first three exons, a small portion of the fourth and a small portion of the fifth exon. Initial work on the protein are on an even shorter sequence composed solely of the majority of exon eight were there may be an alternate translation start site. Initial studies of ZNF292 were of its role as an enhancer in growth hormone expression in somatotrophs. Its only demonstrated DNA binding is to a site (Z-box/ZRE) in the promoter of the growth hormone gene (GH1) where it significantly increases the expression of GH1 by cooperating with two adjacent binding sites for POU1F1 (PIT1) . The Z-box binding site also appears upstream of other related proteins in the growth hormone locus (GH2, CSH1, CSH2 and CSHL). ZNF292 is expressed in many other tissues as well where its function is unknown. ZNF292 is an unusual C2H2 protein in that several of its zinc fingers which cooperate in DNA binding are not closely apposed to one another. Typically C2H2 fingers involved in DNA binding are spaced approximately 7aa appart which allows for sequential binding to triads of base pairs. The three zinc fingers suspected to be involved in binding to the Z-Box are more widely spaced so standard DNA binding prediction software (e.g. zf.princeton.edu) does not work in aggregate. ZNF292 has 13 other zinc fingers of unknown function including a set of four with the classical 7aa spacers between them, but which have no identified binding site. Its closest paralog is RLF (rearranged L-Myc Fusion protein) which has been implicated in maintaining epigenetic states. Much of the current work on ZNF292 is focused on its role in cancers and cell-fate determination mediated by interactions with lncRNAs, but a small number of papers have implicated likely gene disrupting mutations in neurodevelopmental disorders. Other papers have studied the role of a circular RNA derived from the ZNF292 gene (circZNF292) which is involved in the hypoxic response of endothelial cells and angiogenesis. The ExAC database shows a slightly higher number than expected for synonymous and missense variants (syn 268.2/352, z=-3.17;mis 680/741, z=-1.14). Likely loss of function mutations show the importance of this gene with an expected LoF of 51.9, but an observed LoF of 5 (pLI=1.0). Annotated Sequences 
C2H2 Zn Finger C2HC Zn Finger Low complexity region Canonical Isoform (1) [NM_001352444.1] Estimated weight: 304.88KDa 10 20 30 40 50 MADEEAEQER LSCGEGGCVA ELQRLGERLQ ELELQLRESR VPAVEAATDY || 60 70 80 90 100 exon 1/2 CQQLCQTLLE YAEKWKTSED PLPLLEVYTV AIQSYVKARP YLTSECENVA ||0 120 130 || 140 150 exon 2/3/4 LVLERLALSC VELLLCLPVE LSDKQWEQFQ TLVQVAHEKL MENGSCELHF 160 170 1|| 190 200 exon 4/5 LATLAQETGV WKNPVLCTIL SQEPLDKDKV NEFLAFEGPI LLDMRIKHLI 210 220 230 240 ||50 exon 5/6 KTNQLSQATA LAKLCSDHPE IGIKGSFKQT YLVCLCTSSP NGKLIEEISE 260 270 280 290 || 300 exon 6/7 VDCKDALEMI CNLESEGDEK SALVLCTAFL SRQLQQGDMY CAWELTLFWS 310 320 330 34| | 350 exon 7/8 KLQQRVEPSI QVYLERCRQL SLLTKTVYHI FFLIKVINSE TEGAGLATCI 360 370 380 390 400 ELCVKALRLE STENTEVKIS ICKTISCLLP DDLEVKRACQ LSEFLIEPTV 410 420 430 440 450 DAYYAVEMLY NQPDQKYDEE NLPIPNSLRC ELLLVLKTQW PFDPEFWDWK 460 470 480 490 500 TLKRQCLALM GEEASIVSSI DELNDSEVYE KVVDYQEESK ETSMNGLSGG 510 520 530 540 550 VGANSGLLKD IGDEKQKKRE IKQLRERGFI SARFRNWQAY MQYCVLCDKE 560 570 580 590 600 FLGHRIVRHA QKHYKDGIYS CPICAKNFNS KETFVPHVTL HVKQSSKERL znf1/2 610 620 630 640 650 AAMKPLRRLG RPPKITTTNE NQKTNTVAKQ EQRPIKKNSL YSTDFIVFND lcr 660 670 680 690 700 NDGSDDENDD KDKSYEPEVI PVQKPVPVNE FNCPVTFCKK GFKYFKNLIA znf3 710 720 730 740 750 HVKGHKDNED AKRFLEMQSK KVICQYCRRH FVSVTHLNDH LQMHCGSKPY znf3/4 760 770 780 790 800 ICIQMKCKAG FNSYAELLTH RKEHQVFRAK CMFPKCGRIF SEAYLLYDHE znf5/6 810 820 830 840 850 AQHYNTYTCK FTGCGKVYRS QGELEKHLDD HSTPPEKVLP PEAQLNSSGD znf6/7 860 870 880 890 900 SIQPSEVNQN TAENIEKERS MLPSENNIEN SLLADRSDAW DKSKAESAVT 910 920 930 940 950 KQDQISASEL RQANGPLSNG LENPATTPLL QSSEVAVSIK VSLNQGIEDN 960 970 980 990 1000 FGKQENSTVE GSGEALVTDL HTPVEDTCND LCHPGFQERK EQDCFNDAHV 1010 1020 1030 1040 1050 TQNSLVNSET LKIGDLTPQN LERQVNNLMT FSVQNQAAFQ NNLPTSKFEC 1060 1070 1080 1090 1100 GDNVKTSSNL YNLPLKTLES IAFVPPQSDL SNSLGTPSVP PKAPVQKFSC 1110 1120 1130 1140 1150 QVEGCTRTYN SSQSIGKHMK TAHPDQYAAF KMQRKSKKGQ KANNLNTPNN znf8 1160 1170 1180 1190 1200 GKFVYFLPSP VNSSNPFFTS QTKANGNPAC SAQLQHVSPP IFPAHLASVS 1210 1220 1230 1240 1250 TPLLSSMESV INPNITSQDK NEQGGMLCSQ MENLPSTALP AQMEDLTKTV 1260 1270 1280 1290 1300 LPLNIDSGSD PFLPLPAESS SMSLFPSPAD SGTNSVFSQL ENNTNHYSSQ 1310 1320 1330 1340 1350 IEGNTNSSFL KGGNGENAVF PSQVNVANNF SSTNAQQSAP EKVKKDRGRG 1360 1370 1380 1390 1400 PNGKERKPKH NKRAKWPAII RDGKFICSRC YRAFTNPRSL GGHLSKRSYC znf9 1410 1420 1430 1440 1450 KPLDGAEIAQ ELLQSNGQPS LLASMILSTN AVNLQQPQQS TFNPEACFKD 1460 1470 1480 1490 1500 PSFLQLLAEN RSPAFLPNTF PRSGVTNFNT SVSQEGSEII KQALETAGIP 1510 1520 1530 1540 1550 STFEGAEMLS HVSTGCVSDA SQVNATVMPN PTVPPLLHTV CHPNTLLTNQ 1560 1570 1580 1590 1600 NRTSNSKTSS IEECSSLPVF PTNDLLLKTV ENGLCSSSFP NSGGPSQNFT 1610 1620 1630 1640 1650 SNSSRVSVIS GPQNTRSSHL NKKGNSASKR RKKVAPPLIA PNASQNLVTS 1660 1670 1680 1690 1700 DLTTMGLIAK SVEIPTTNLH SNVIPTCEPQ SLVENLTQKL NNVNNQLFMT 1710 1720 1730 1740 1750 DVKENFKTSL ESHTVLAPLT LKTENGDSQM MALNSCTTSI NSDLQISEDN 1760 1770 1780 1790 1800 VIQNFEKTLE IIKTAMNSQI LEVKSGSQGA GETSQNAQIN YNIQLPSVNT 1810 1820 1830 1840 1850 VQNNKLPDSS PFSSFISVMP TKSNIPQSEV SHKEDQIQEI LEGLQKLKLE 1860 1870 1880 1890 1900 NDLSTPASQC VLINTSVTLT PTPVKSTADI TVIQPVSEMI NIQFNDKVNK 1910 1920 1930 1940 1950 PFVCQNQGCN YSAMTKDALF KHYGKIHQYT PEMILEIKKN QLKFAPFKCV znf10/11 1960 1970 1980 1990 2000 VPTCTKTFTR NSNLRAHCQL VHHFTTEEMV KLKIKRPYGR KSQSENVPAS znf11 2010 2020 2030 2040 2050 RSTQVKKQLA MTEENKKESQ PALELRAETQ NTHSNVAVIP EKQLVEKKSP 2060 2070 2080 2090 2100 DKTESSLQVI TVTSEQCNTN ALTNTQTKGR KIRRHKKEKE EKKRKKPVSQ 2110 2120 2130 2140 2150 SLEFPTRYSP YRPYRCVHQG CFAAFTIQQN LILHYQAVHK SDLPAFSAEV znf12 2160 2170 2180 2190 2200 EEESEAGKES EETETKQTLK EFRCQVSDCS RIFQAITGLI QHYMKLHEMT znf13 2210 2220 2230 2240 2250 PEEIESMTAS VDVGKFPCDQ LECKSSFTTY LNYVVHLEAD HGIGLRASKT znf14 2260 2270 2280 2290 2300 EEDGVYKCDC EGCDRIYATR SNLLRHIFNK HNDKHKAHLI RPRRLTPGQE znf15 2310 2320 2330 2340 2350 NMSSKANQEK SKSKHRGTKH SRCGKEGIKM PKTKRKKKNN LENKNAKIVQ lcr 2360 2370 2380 2390 2400 IEENKPYSLK RGKHVYSIKA RNDALSECTS RFVTQYPCMI KGCTSVVTSE znf16 2410 2420 2430 2440 2450 SNIIRHYKCH KLSKAFTSQH RNLLIVFKRC CNSQVKETSE QEGAKNDVKD znf16 2460 2470 2480 2490 2500 SDTCVSESND NSRTTATVSQ KEVEKNEKDE MDELTELFIT KLINEDSTSV 2510 2520 2530 2540 2550 ETQANTSSNV SNDFQEDNLC QSERQKASNL KRVNKEKNVS QNKRKVEKA 2560 2570 2580 2590 2600 EPASAAELSS VRKEEETAVA IQTIEEHPAS FDWSSFKPMG FEVSFLKFLE 2610 2620 2630 2640 2650 ESAVKQKKNT DKDHPNTGNK KGSHSNSRKN IDKTAVTSGN HVCPCKESET 2660 2670 2680 2690 2700 FVQFANPSQL QCSDNVKIVL DKNLKDCTEL VLKQLQEMKP TVSLKKLEVH 2710 2720 SNDPDMSVMK DISIGKATGR GQY Isoform 2 [NM_015021.2] Estimated weight: 288.34KDa 10 20 30 ||40 50 MENGSCELHF LATLAQETGV WKNPVLCTIL SQEPLDKDKA FEGPILLDMR exon 4(part)/5(part) 60 70 80 90 100 IKHLIKTNQL SQATALAKLC SDHPEIGIKG SFKQTYLVCL CTSSPNGKLI || 110 120 130 140 ||0 exon 5/6/7 EEISEVDCKD ALEMICNLES EGDEKSALVL CTAFLSRQLQ QGDMYCAWEL 160 170 180 190 || 200 exon 7/8 TLFWSKLQQR VEPSIQVYLE RCRQLSLLTK TVYHIFFLIK VINSETEGAG 210 220 230 240 250 LATCIELCVK ALRLESTENT EVKISICKTI SCLLPDDLEV KRACQLSEFL 260 270 280 290 300 IEPTVDAYYA VEMLYNQPDQ KYDEENLPIP NSLRCELLLV LKTQWPFDPE 310 320 330 340 350 FWDWKTLKRQ CLALMGEEAS IVSSIDELND SEVYEKVVDY QEESKETSMN 360 370 380 390 400 GLSGGVGANS GLLKDIGDEK QKKREIKQLR ERGFISARFR NWQAYMQYCV zf1 410 420 430 440 450 LCDKEFLGHR IVRHAQKHYK DGIYSCPICA KNFNSKETFV PHVTLHVKQS zf1/zf2 460 470 480 490 500 SKERLAAMKP LRRLGRPPKI TTTNENQKTN TVAKQEQRPI KKNSLYSTDF 510 520 530 540 550 IVFNDNDGSD DENDDKDKSY EPEVIPVQKP VPVNEFNCPV TFCKKGFKYF 560 570 580 590 600 KNLIAHVKGH KDNEDAKRFL EMQSKKVICQ YCRRHFVSVT HLNDHLQMHC zf3/zf4 610 620 630 640 650 GSKPYICIQM KCKAGFNSYA ELLTHRKEHQ VFRAKCMFPK CGRIFSEAYL zf5/zf6 660 670 680 690 700 LYDHEAQHYN TYTCKFTGCG KVYRSQGELE KHLDDHSTPP EKVLPPEAQL zf6/zf7 710 720 730 740 750 NSSGDSIQPS EVNQNTAENI EKERSMLPSE NNIENSLLAD RSDAWDKSKA 760 770 780 790 800 ESAVTKQDQI SASELRQANG PLSNGLENPA TTPLLQSSEV AVSIKVSLNQ 810 820 830 840 850 GIEDNFGKQE NSTVEGSGEA LVTDLHTPVE DTCNDLCHPG FQERKEQDCF 860 870 880 890 900 NDAHVTQNSL VNSETLKIGD LTPQNLERQV NNLMTFSVQN QAAFQNNLPT 910 920 930 940 950 SKFECGDNVK TSSNLYNLPL KTLESIAFVP PQSDLSNSLG TPSVPPKAPV 960 970 980 990 1000 QKFSCQVEGC TRTYNSSQSI GKHMKTAHPD QYAAFKMQRK SKKGQKANNL zf8 1010 1020 1030 1040 1050 NTPNNGKFVY FLPSPVNSSN PFFTSQTKAN GNPACSAQLQ HVSPPIFPAH 1060 1070 1080 1090 1100 LASVSTPLLS SMESVINPNI TSQDKNEQGG MLCSQMENLP STALPAQMED 1110 1120 1130 1140 1150 LTKTVLPLNI DSGSDPFLPL PAESSSMSLF PSPADSGTNS VFSQLENNTN 1160 1170 1180 1190 1200 HYSSQIEGNT NSSFLKGGNG ENAVFPSQVN VANNFSSTNA QQSAPEKVKK 1210 1220 1230 1240 1250 DRGRGPNGKE RKPKHNKRAK WPAIIRDGKF ICSRCYRAFT NPRSLGGHLS zf9 1260 1270 1280 1290 1300 KRSYCKPLDG AEIAQELLQS NGQPSLLASM ILSTNAVNLQ QPQQSTFNPE 1310 1320 1330 1340 1350 ACFKDPSFLQ LLAENRSPAF LPNTFPRSGV TNFNTSVSQE GSEIIKQALE 1360 1370 1380 1390 1400 TAGIPSTFEG AEMLSHVSTG CVSDASQVNA TVMPNPTVPP LLHTVCHPNT 1410 1420 1430 1440 1450 LLTNQNRTSN SKTSSIEECS SLPVFPTNDL LLKTVENGLC SSSFPNSGGP 1460 1470 1480 1490 1500 SQNFTSNSSR VSVISGPQNT RSSHLNKKGN SASKRRKKVA PPLIAPNASQ 1510 1520 1530 1540 1550 NLVTSDLTTM GLIAKSVEIP TTNLHSNVIP TCEPQSLVEN LTQKLNNVNN 1560 1570 1580 1590 1600 QLFMTDVKEN FKTSLESHTV LAPLTLKTEN GDSQMMALNS CTTSINSDLQ 1610 1620 1630 1640 1650 ISEDNVIQNF EKTLEIIKTA MNSQILEVKS GSQGAGETSQ NAQINYNIQL 1660 1670 1680 1690 1700 PSVNTVQNNK LPDSSPFSSF ISVMPTKSNI PQSEVSHKED QIQEILEGLQ 1710 1720 1730 1740 1750 KLKLENDLST PASQCVLINT SVTLTPTPVK STADITVIQP VSEMINIQFN 1760 1770 1780 1790 1800 DKVNKPFVCQ NQGCNYSAMT KDALFKHYGK IHQYTPEMIL EIKKNQLKFA zf10 1810 1820 1830 1840 1850 PFKCVVPTCT KTFTRNSNLR AHCQLVHHFT TEEMVKLKIK RPYGRKSQSE zf11 1860 1870 1880 1890 1900 NVPASRSTQV KKQLAMTEEN KKESQPALEL RAETQNTHSN VAVIPEKQLV 1910 1920 1930 1940 1950 EKKSPDKTES SLQVITVTSE QCNTNALTNT QTKGRKIRRH KKEKEEKKRK 1960 1970 1980 1990 2000 KPVSQSLEFP TRYSPYRPYR CVHQGCFAAF TIQQNLILHY QAVHKSDLPA zf12 2010 2020 2030 2040 2050 FSAEVEEESE AGKESEETET KQTLKEFRCQ VSDCSRIFQA ITGLIQHYMK zf13 2060 2070 2080 2090 2100 LHEMTPEEIE SMTASVDVGK FPCDQLECKS SFTTYLNYVV HLEADHGIGL zf13/zf14 2110 2120 2130 2140 2150 RASKTEEDGV YKCDCEGCDR IYATRSNLLR HIFNKHNDKH KAHLIRPRRL zf15 2160 2170 2180 2190 2200 TPGQENMSSK ANQEKSKSKH RGTKHSRCGK EGIKMPKTKR KKKNNLENKN 2210 2220 2230 2240 2250 AKIVQIEENK PYSLKRGKHV YSIKARNDAL SECTSRFVTQ YPCMIKGCTS zf16 2260 2270 2280 2290 2300 VVTSESNIIR HYKCHKLSKA FTSQHRNLLI VFKRCCNSQV KETSEQEGAK znf16 2310 2320 2330 2340 2350 NDVKDSDTCV SESNDNSRTT ATVSQKEVEK NEKDEMDELT ELFITKLINE 2360 2370 2380 2390 2400 DSTSVETQAN TSSNVSNDFQ EDNLCQSERQ KASNLKRVNK EKNVSQNKKR 2410 2420 2430 2440 2450 KVEKAEPASA AELSSVRKEE ETAVAIQTIE EHPASFDWSS FKPMGFEVSF nls 2460 2470 2480 2490 2500 LKFLEESAVK QKKNTDKDHP NTGNKKGSHS NSRKNIDKTA VTSGNHVCPC 2510 2520 2530 2540 2550 KESETFVQFA NPSQLQCSDN VKIVLDKNLK DCTELVLKQL QEMKPTVSLK 2560 2570 KLEVHSNDPD MSVMKDISIG KATGRGQY
Raw Sequence (FASTA)
Isoform 1 >sp|O60281|ZN292_HUMAN Zinc finger protein 292 OS=Homo sapiens OX=9606 GN=ZNF292 PE=1 SV=3 MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQTLLE YAEKWKTSEDPLPLLEVYTVAIQSYVKARPYLTSECENVALVLERLALSCVELLLCLPVE LSDKQWEQFQTLVQVAHEKLMENGSCELHFLATLAQETGVWKNPVLCTILSQEPLDKDKV NEFLAFEGPILLDMRIKHLIKTNQLSQATALAKLCSDHPEIGIKGSFKQTYLVCLCTSSP NGKLIEEISEVDCKDALEMICNLESEGDEKSALVLCTAFLSRQLQQGDMYCAWELTLFWS KLQQRVEPSIQVYLERCRQLSLLTKTVYHIFFLIKVINSETEGAGLATCIELCVKALRLE STENTEVKISICKTISCLLPDDLEVKRACQLSEFLIEPTVDAYYAVEMLYNQPDQKYDEE NLPIPNSLRCELLLVLKTQWPFDPEFWDWKTLKRQCLALMGEEASIVSSIDELNDSEVYE KVVDYQEESKETSMNGLSGGVGANSGLLKDIGDEKQKKREIKQLRERGFISARFRNWQAY MQYCVLCDKEFLGHRIVRHAQKHYKDGIYSCPICAKNFNSKETFVPHVTLHVKQSSKERL AAMKPLRRLGRPPKITTTNENQKTNTVAKQEQRPIKKNSLYSTDFIVFNDNDGSDDENDD KDKSYEPEVIPVQKPVPVNEFNCPVTFCKKGFKYFKNLIAHVKGHKDNEDAKRFLEMQSK KVICQYCRRHFVSVTHLNDHLQMHCGSKPYICIQMKCKAGFNSYAELLTHRKEHQVFRAK CMFPKCGRIFSEAYLLYDHEAQHYNTYTCKFTGCGKVYRSQGELEKHLDDHSTPPEKVLP PEAQLNSSGDSIQPSEVNQNTAENIEKERSMLPSENNIENSLLADRSDAWDKSKAESAVT KQDQISASELRQANGPLSNGLENPATTPLLQSSEVAVSIKVSLNQGIEDNFGKQENSTVE GSGEALVTDLHTPVEDTCNDLCHPGFQERKEQDCFNDAHVTQNSLVNSETLKIGDLTPQN LERQVNNLMTFSVQNQAAFQNNLPTSKFECGDNVKTSSNLYNLPLKTLESIAFVPPQSDL SNSLGTPSVPPKAPVQKFSCQVEGCTRTYNSSQSIGKHMKTAHPDQYAAFKMQRKSKKGQ KANNLNTPNNGKFVYFLPSPVNSSNPFFTSQTKANGNPACSAQLQHVSPPIFPAHLASVS TPLLSSMESVINPNITSQDKNEQGGMLCSQMENLPSTALPAQMEDLTKTVLPLNIDSGSD PFLPLPAESSSMSLFPSPADSGTNSVFSQLENNTNHYSSQIEGNTNSSFLKGGNGENAVF PSQVNVANNFSSTNAQQSAPEKVKKDRGRGPNGKERKPKHNKRAKWPAIIRDGKFICSRC YRAFTNPRSLGGHLSKRSYCKPLDGAEIAQELLQSNGQPSLLASMILSTNAVNLQQPQQS TFNPEACFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIP STFEGAEMLSHVSTGCVSDASQVNATVMPNPTVPPLLHTVCHPNTLLTNQNRTSNSKTSS IEECSSLPVFPTNDLLLKTVENGLCSSSFPNSGGPSQNFTSNSSRVSVISGPQNTRSSHL NKKGNSASKRRKKVAPPLIAPNASQNLVTSDLTTMGLIAKSVEIPTTNLHSNVIPTCEPQ SLVENLTQKLNNVNNQLFMTDVKENFKTSLESHTVLAPLTLKTENGDSQMMALNSCTTSI NSDLQISEDNVIQNFEKTLEIIKTAMNSQILEVKSGSQGAGETSQNAQINYNIQLPSVNT VQNNKLPDSSPFSSFISVMPTKSNIPQSEVSHKEDQIQEILEGLQKLKLENDLSTPASQC VLINTSVTLTPTPVKSTADITVIQPVSEMINIQFNDKVNKPFVCQNQGCNYSAMTKDALF KHYGKIHQYTPEMILEIKKNQLKFAPFKCVVPTCTKTFTRNSNLRAHCQLVHHFTTEEMV KLKIKRPYGRKSQSENVPASRSTQVKKQLAMTEENKKESQPALELRAETQNTHSNVAVIP EKQLVEKKSPDKTESSLQVITVTSEQCNTNALTNTQTKGRKIRRHKKEKEEKKRKKPVSQ SLEFPTRYSPYRPYRCVHQGCFAAFTIQQNLILHYQAVHKSDLPAFSAEVEEESEAGKES EETETKQTLKEFRCQVSDCSRIFQAITGLIQHYMKLHEMTPEEIESMTASVDVGKFPCDQ LECKSSFTTYLNYVVHLEADHGIGLRASKTEEDGVYKCDCEGCDRIYATRSNLLRHIFNK HNDKHKAHLIRPRRLTPGQENMSSKANQEKSKSKHRGTKHSRCGKEGIKMPKTKRKKKNN LENKNAKIVQIEENKPYSLKRGKHVYSIKARNDALSECTSRFVTQYPCMIKGCTSVVTSE SNIIRHYKCHKLSKAFTSQHRNLLIVFKRCCNSQVKETSEQEGAKNDVKDSDTCVSESND NSRTTATVSQKEVEKNEKDEMDELTELFITKLINEDSTSVETQANTSSNVSNDFQEDNLC QSERQKASNLKRVNKEKNVSQNKKRKVEKAEPASAAELSSVRKEEETAVAIQTIEEHPAS FDWSSFKPMGFEVSFLKFLEESAVKQKKNTDKDHPNTGNKKGSHSNSRKNIDKTAVTSGN HVCPCKESETFVQFANPSQLQCSDNVKIVLDKNLKDCTELVLKQLQEMKPTVSLKKLEVH SNDPDMSVMKDISIGKATGRGQY Isoform 2 >sp|O60281-2|ZN292_HUMAN Isoform 2 of Zinc finger protein 292 OS=Homo sapiens OX=9606 GN=ZNF292 MENGSCELHFLATLAQETGVWKNPVLCTILSQEPLDKDKAFEGPILLDMRIKHLIKTNQL SQATALAKLCSDHPEIGIKGSFKQTYLVCLCTSSPNGKLIEEISEVDCKDALEMICNLES EGDEKSALVLCTAFLSRQLQQGDMYCAWELTLFWSKLQQRVEPSIQVYLERCRQLSLLTK TVYHIFFLIKVINSETEGAGLATCIELCVKALRLESTENTEVKISICKTISCLLPDDLEV KRACQLSEFLIEPTVDAYYAVEMLYNQPDQKYDEENLPIPNSLRCELLLVLKTQWPFDPE FWDWKTLKRQCLALMGEEASIVSSIDELNDSEVYEKVVDYQEESKETSMNGLSGGVGANS GLLKDIGDEKQKKREIKQLRERGFISARFRNWQAYMQYCVLCDKEFLGHRIVRHAQKHYK DGIYSCPICAKNFNSKETFVPHVTLHVKQSSKERLAAMKPLRRLGRPPKITTTNENQKTN TVAKQEQRPIKKNSLYSTDFIVFNDNDGSDDENDDKDKSYEPEVIPVQKPVPVNEFNCPV TFCKKGFKYFKNLIAHVKGHKDNEDAKRFLEMQSKKVICQYCRRHFVSVTHLNDHLQMHC GSKPYICIQMKCKAGFNSYAELLTHRKEHQVFRAKCMFPKCGRIFSEAYLLYDHEAQHYN TYTCKFTGCGKVYRSQGELEKHLDDHSTPPEKVLPPEAQLNSSGDSIQPSEVNQNTAENI EKERSMLPSENNIENSLLADRSDAWDKSKAESAVTKQDQISASELRQANGPLSNGLENPA TTPLLQSSEVAVSIKVSLNQGIEDNFGKQENSTVEGSGEALVTDLHTPVEDTCNDLCHPG FQERKEQDCFNDAHVTQNSLVNSETLKIGDLTPQNLERQVNNLMTFSVQNQAAFQNNLPT SKFECGDNVKTSSNLYNLPLKTLESIAFVPPQSDLSNSLGTPSVPPKAPVQKFSCQVEGC TRTYNSSQSIGKHMKTAHPDQYAAFKMQRKSKKGQKANNLNTPNNGKFVYFLPSPVNSSN PFFTSQTKANGNPACSAQLQHVSPPIFPAHLASVSTPLLSSMESVINPNITSQDKNEQGG MLCSQMENLPSTALPAQMEDLTKTVLPLNIDSGSDPFLPLPAESSSMSLFPSPADSGTNS VFSQLENNTNHYSSQIEGNTNSSFLKGGNGENAVFPSQVNVANNFSSTNAQQSAPEKVKK DRGRGPNGKERKPKHNKRAKWPAIIRDGKFICSRCYRAFTNPRSLGGHLSKRSYCKPLDG AEIAQELLQSNGQPSLLASMILSTNAVNLQQPQQSTFNPEACFKDPSFLQLLAENRSPAF LPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNA TVMPNPTVPPLLHTVCHPNTLLTNQNRTSNSKTSSIEECSSLPVFPTNDLLLKTVENGLC SSSFPNSGGPSQNFTSNSSRVSVISGPQNTRSSHLNKKGNSASKRRKKVAPPLIAPNASQ NLVTSDLTTMGLIAKSVEIPTTNLHSNVIPTCEPQSLVENLTQKLNNVNNQLFMTDVKEN FKTSLESHTVLAPLTLKTENGDSQMMALNSCTTSINSDLQISEDNVIQNFEKTLEIIKTA MNSQILEVKSGSQGAGETSQNAQINYNIQLPSVNTVQNNKLPDSSPFSSFISVMPTKSNI PQSEVSHKEDQIQEILEGLQKLKLENDLSTPASQCVLINTSVTLTPTPVKSTADITVIQP VSEMINIQFNDKVNKPFVCQNQGCNYSAMTKDALFKHYGKIHQYTPEMILEIKKNQLKFA PFKCVVPTCTKTFTRNSNLRAHCQLVHHFTTEEMVKLKIKRPYGRKSQSENVPASRSTQV KKQLAMTEENKKESQPALELRAETQNTHSNVAVIPEKQLVEKKSPDKTESSLQVITVTSE QCNTNALTNTQTKGRKIRRHKKEKEEKKRKKPVSQSLEFPTRYSPYRPYRCVHQGCFAAF TIQQNLILHYQAVHKSDLPAFSAEVEEESEAGKESEETETKQTLKEFRCQVSDCSRIFQA ITGLIQHYMKLHEMTPEEIESMTASVDVGKFPCDQLECKSSFTTYLNYVVHLEADHGIGL RASKTEEDGVYKCDCEGCDRIYATRSNLLRHIFNKHNDKHKAHLIRPRRLTPGQENMSSK ANQEKSKSKHRGTKHSRCGKEGIKMPKTKRKKKNNLENKNAKIVQIEENKPYSLKRGKHV YSIKARNDALSECTSRFVTQYPCMIKGCTSVVTSESNIIRHYKCHKLSKAFTSQHRNLLI VFKRCCNSQVKETSEQEGAKNDVKDSDTCVSESNDNSRTTATVSQKEVEKNEKDEMDELT ELFITKLINEDSTSVETQANTSSNVSNDFQEDNLCQSERQKASNLKRVNKEKNVSQNKKR KVEKAEPASAAELSSVRKEEETAVAIQTIEEHPASFDWSSFKPMGFEVSFLKFLEESAVK QKKNTDKDHPNTGNKKGSHSNSRKNIDKTAVTSGNHVCPCKESETFVQFANPSQLQCSDN VKIVLDKNLKDCTELVLKQLQEMKPTVSLKKLEVHSNDPDMSVMKDISIGKATGRGQY |